Search results for "MSC therapeutic properties"

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Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Primin…

2022

Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these cells are expanded in two-dimensional (2D) cultures, and, in that case, MSCs undergo genotypic/phenotypic changes resulting in a loss of their therapeutic capabilities. Moreover, several clinical trials using MSCs have shown controversial results with moderate/insufficient therapeutic responses. Different priming methods were tested to improve MSC effects, and three-dimensional (3D) culturing techniques were also examined. MSC spheroids display increased therapeutic properties, and, in this context, it is crucial…

QH301-705.5Cell Culture TechniquesCell SeparationRegenerative MedicineArticleCatalysisEpigenesis GeneticImmunophenotypingInorganic ChemistryHumansAmnionPhysical and Theoretical ChemistryBiology (General)Molecular BiologyQD1-999SpectroscopyCells CulturedGene Expression ProfilingOrganic ChemistryComputational BiologyRNA sequencingCell DifferentiationMesenchymal Stem CellsMolecular Sequence AnnotationGeneral MedicineMSC therapeutic propertiesComputer Science ApplicationsChemistryGene OntologyMSC spheroidsGene Expression Regulationhuman amnion-derived mesenchymal stromal/stem cells; RNA sequencing; 3D priming; MSC spheroids; MSC therapeutic properties; regenerative medicineHuman amnion-derived mesenchymal stromal/stem cells3D primingTranscriptomeBiomarkers

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PEPhysical Sciences and Engineering
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